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The Difference Between Active vs. Inactive Functional Ingredients in Skincare Formulations

by Ané Auret 12 min read

The Difference Between Active vs. Inactive Functional Ingredients in Skincare Formulations

Skincare isn't just about what individual ingredients do; it's about how they work together in the final formulation. 

Following on from the previous blog about"How To Read and Understand Skincare Ingredient Lists / INCIs"we are going to do a deeper dive into the different types ingredients that you find on your INCI. 

In today's blog we're exploring the difference between 'active' ingredients and "inactive" (functional) ingredients on your skincare ingredient list (INCI) so that you can know more about the science behind your favourite products and how they fit and work together in a formulation.   

We debunk some skincare and ingredient myths, explain the fascinating science of Rheology and list out some examples of active and "inactive ingredients used in skincare and cosmetics. 

*** There is also a sample Retinal & Peptide serum formulation at the end if you want to see what this looks like. 

Skincare formulation is a fascinating blend of disciplines.

When I look at what cosmetic scientists and formulators do what comes to mind is a carefully orchestrated dance of science, art, and something just a little bit magical.

I like to think of it as 97% science—the precision of chemistry and biology; 2% art—the creativity in texture and feel—and 1% magic—that inexplicable spark that transforms ingredients into something truly special. 

Ok - I know it's actually all science, but I've seen chemists work magic with a formulation with tricks of the trade up their sleeve and years of experience.  If you ever get the chance to be in the lab where these formulations are created I'd recommend it.  

In our previous blog we talked about "How to read the Ingredient list (INCI) on your product packaging".  

Today, we're diving deeper into the actual ingredients that are listed and a crucial distinction: the difference between "active" and "inactive" (functional) ingredients.

Personally I disagree with this description because the ingredients typically described as “inactive” are anything but - every ingredient in your formulation has a role and purpose so there really is no thing such as an “inactive” ingredient.

Saying that - I do understand the sentiment or reason for describing it this way because we do need to make the distinction and it's an important part of reading your ingredient list.

We know that it is the well-known, much talked about “active” ingredients like the Retinoids and Vitamin C’s and peptides that get all the limelight, but today we're also talking about the rest of the ingredients in your product that is not recognised that much. 

The Science of Rheology in Skincare 

“Active” ingredients aside for a moment - there is a huge field in science called Rheology - the science of how materials flow and deform. In cosmetic science, rheology is absolutely crucial.

It dictates how a product feels on your skin, how easily it spreads, and how effectively it delivers its active ingredients

In essence, Rheology is the bridge between a product's formulation and its performance.

Cosmetic chemists carefully manipulate rheological properties to create products that not only deliver effective results but also provide a pleasant and luxurious user experience.

They use a variety of functional ingredients, like viscosity enhancers, emulsifiers, and stabilisers, to achieve the desired rheological profile. 

We cover this category further down in the blog so you can see how these ingredients work alongside your “active” ingredients to create a fully formed product that is stable, pleasant to use and supports the results that you’re getting.

Understanding this difference will empower you to make informed choices about your skincare, ensuring you're getting the results you desire.

Before we dive into the main part of the blog I feel it’s important to debunk a few important points about ingredients used in skincare.

1. Addressing the "Chemical-Free" Skincare Myth: A Scientific Reality Check

One of the most misleading and frankly, scientifically inaccurate, marketing claims in the skincare industry is the notion of being "chemical-free." If a brand uses this it should be a big red flag as it shows a misunderstanding of basic chemistry and I would have questions about this. 

This phrase preys on consumer fears, implying that "chemicals" are inherently harmful.

The reality is that everything is a chemical. Water (H2O), the air we breathe (a mixture of gases), and the natural oils derived from plants are all composed of chemicals.

To suggest that a product is "chemical-free" is not only misleading but fundamentally impossible.

In fact, if a product truly contained no chemicals, it wouldn't exist.

Brands using this term are exploiting a lack of scientific understanding and fostering unnecessary fear.

It's time to embrace the reality that chemistry is the foundation of everything, including the very products designed to enhance our skin's health, longevity and beauty.

2. Natural vs. Synthetic: Understanding the Difference - and the myth that “Natural is Better / Safer”

Another common misconception is that "natural" ingredients are safer and superior to "synthetic" ones.

I’ve found over the years that when someone asks me about “chemicals” in a product, it often refers to a “synthetic” ingredient - not always, but it has happened often enough.

While natural ingredients can offer valuable benefits, it's crucial to understand that "natural" does not automatically equate to "safe" or "effective."

A very well-known example is Poison Ivy - which is natural, but you wouldn't put it on your face.

Similarly, synthetic ingredients are created in a lab - they undergo rigorous testing and can be purer and more consistent than their natural counterparts. They are also often much more environmentally friendly and sustainable as they don’t make use of natural resources. 

  • Natural Ingredients:
    • Derived from plants, minerals, or animal sources.
    • Can be complex mixtures of various compounds.
    • May vary in quality and potency depending on sourcing and processing.
    • Can be potential allergens due to their complexity.
  • Synthetic Ingredients:
    • Created in a laboratory through chemical synthesis.
    • Can be precisely controlled for purity and consistency.
    • Often undergo extensive safety testing.
    • Can be designed to mimic or improve upon natural ingredients.
    • Can be more sustainable than natural counterparts.

The choice between natural and synthetic ingredients should be based on scientific evidence, safety data, and efficacy, not on fear-mongering marketing claims. 

I've also seen brands who claim that they are all "natural" just to spot a peptide or some other synthetically derived ingredient(s) on an ingredient list. 

Many synthetic ingredients are nature-identical and are created to be a pure and safe version of a natural ingredient.

Every brand has its own philosophy when it comes to its ingredient choices and how it communicates that to its customers. 

I can only speak for myself - and at Beauty by Ané Skincare our approach is to use a combination of natural and synthetically derived ingredientsbecause I believe that gives us the best opportunity to create the high-performance skincare that we want to offer you.

I love the benefits that ingredients like Retinaldehyde, different types of peptides, Vitamin C derivatives and several other synthetic options can safely bring to our formulations - and most importantly to our customers and their skin concerns and goals.

I also love that we are in a position where modern science allows us to combine some of the best, cutting-edge synthetic ingredients with natural ingredients like botanical oils and extracts that have been around for centuries - and that we can bring all of this together in one formulation to offer you the best products we can and support you in your skin journey.

To me, this is an ideal path to follow, but it’s important that we all have the relevant information to make the best decisions according to our own needs. 

It's a decision only you can make. Always reach out to the brand directly if you have any questions about this. 

3. Addressing the Misconception: "Active" vs. "Inactive" and the Myth of "Fillers"

As we've seen above it's common to hear skincare ingredients categorised as "active" and "inactive," implying that the latter are simply fillers or unnecessary components.

This is a significant misconception. In reality, functional ingredients are far from 'inactive'; they are essential for the product's efficacy, stability, and user experience.

  • The Problem with "Inactive":
    • The term "inactive" suggests that these ingredients have no role in the product's performance and / or can have no impact on the skin. 
    • This misrepresentation undervalues the critical functions they perform.
    • It can lead consumers to believe that only "active" ingredients matter, which is far from the truth.
  • Functional Ingredients: The Unsung Heroes:
    • Functional ingredients are the backbone of any skincare formulation.
    • They ensure that the active ingredients are delivered effectively and safely.
    • They contribute to the product's texture, spreadability, and absorption.
    • They play a vital role in preserving the product's stability and shelf life.

4. Debunking the Myth of "Fillers" in Skincare 

    • The notion that some ingredients are merely "fillers" is a myth.
    • Every ingredient in a well-formulated product serves a purpose.
    • Solvents, for example, are not just "fillers"; they are essential for dissolving and dispersing other ingredients.
    • Viscosity enhancers are not just there to make a product thick, they are there to help control the release of the active ingredients, and create a pleasing skin feel.
    • Emulsifiers allow oil and water to mix, creating stable creams and lotions.
    • Preservatives are crucial for preventing bacterial and fungal growth, ensuring product safety.
    • Each ingredient is carefully selected to contribute to the overall effectiveness and usability of the product.

What Are “Active” Ingredients In Skincare? 

Active ingredients are the workhorses of your skincare routine.

There are thousands of different ingredients and their derivatives on the market so we will cover only the main categories/ingredient families with some of the more well-known and familiar examples.

These are the components scientifically proven to address specific skin concerns.

They're the ingredients that deliver the promised results, whether it's reducing wrinkles and fine lines, clearing acne, or brightening hyperpigmentation.

  • Purpose:
    • Target specific skin concerns.
    • Can produce measurable changes in the skin.
    • Backed by scientific research and clinical trials.

Examples of Active Ingredients:

1. Retinoids (Vitamin A Derivatives):

    • Retinol, Tretinoin, Retinaldehyde, Retinyl Palmitate
    • Stimulate collagen production, reduce wrinkles, improve texture, treat acne.

2. Alpha Hydroxy Acids (AHAs):

    • Glycolic Acid, Lactic Acid, Malic Acid, Tartaric Acid, Citric Acid
    • Exfoliate, improve texture, reduce hyperpigmentation.

3. Beta Hydroxy Acids (BHAs):

    • Salicylic Acid
    • Exfoliate pores, treat acne, reduce oil production.

4.Antioxidants - Purpose:

      • Neutralise free radicals.
      • Protect against environmental damage.
      • Reduce signs of ageing.
      • Soothe inflammation.

Vitamin-Based Antioxidants:

      • Vitamin C (L-Ascorbic Acid, Ascorbyl Glucoside, Sodium Ascorbyl Phosphate)
      • Vitamin E (Tocopherol, Tocopheryl Acetate)
      • Niacinamide (Vitamin B3)

Plant Extract Antioxidants:

      • Green Tea Extract (Camellia Sinensis)
      • Resveratrol (from grapes)
      • Grape Seed Extract
      • Licorice Root Extract
      • Pomegranate Extract

5. Brighteners/Anti-Pigmentation: To Help Reduce hyperpigmentation, even skin tone, and brighten complexion.

    • Kojic Acid
    • Azelaic Acid
    • Arbutin
    • Niacinamide
    • Licorice Root Extract
    • Tranexamic Acid
    • Hydroquinone (prescription only)

6. Humectants: To Attract and retain moisture in the skin.

    • Hyaluronic Acid (Sodium Hyaluronate)
    • Glycerin
    • Aloe Vera
    • Propylene Glycol
    • Purpose:

7. Emollients (Including Plant Oils, EFAs, and Sterols): To Help Soften, smooth, and Moisturise the skin; and strengthen the skin barrier.

    • Plant Oils:
      • Jojoba Oil
      • Argan Oil
      • Rosehip Oil
      • Squalane (derived from olives)

                       Essential Fatty Acids (EFAs):

      • Linoleic Acid (Omega-6)
      • Alpha-Linolenic Acid (Omega-3)
    • Sterols:
      • Cholesterol
      • Phytosterols

8. Occlusives: To form a protective barrier on the skin's surface, preventing moisture loss.

    • Petrolatum
    • Mineral Oil
    • Beeswax
    • Silicone (Dimethicone, Cyclopentasiloxane)


9. Peptides (Various Types): Improve skin firmness, reduce wrinkles, and enhance skin repair.

    • Signal Peptides: Stimulate collagen and elastin production (e.g., Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7
    • Carrier Peptides: Deliver copper and other trace elements to the skin (e.g., Copper Tripeptide-1)
    • Neurotransmitter-Inhibiting Peptides: Reduce muscle contractions, minimising wrinkles (e.g., Acetyl Hexapeptide-8)
    • Enzyme-Inhibiting Peptides: Inhibit enzymes that break down collagen (e.g., Soy Peptide)
    • Barrier-Strengthening Peptides: Enhance the skin's natural defensive barrier.

10. Growth Factors:

    • Proteins that stimulate cellular growth and repair.
    • Examples: Epidermal Growth Factor (EGF), Transforming Growth Factor (TGF).
    • Purpose: Promote collagen production, improve skin elasticity, accelerate wound healing.

11. Exosomes:

    • Extracellular vesicles released by cells that carry various molecules, including proteins and nucleic acids.
    • Purpose: Facilitate cell-to-cell communication, promote skin regeneration, and reduce inflammation.

    What Are "Inactive" (Functional) Ingredients In Skincare? 

    Also known as “Inactive” Ingredients - I’m sure you’ll see below that they do work very hard in your formulation and that’s why I prefer to refer to them as ‘Functional’ ingredients. 

    Functional ingredients are the supporting cast of your skincare products.

    They don't directly address skin concerns, but they're essential for the product's texture, stability, and overall usability.

    • Purpose:
      • Enhance the product's texture and feel.
      • Ensure the product's stability and shelf life.
      • Facilitate the delivery of active ingredients.
    • Functionality:
      • Influence the product's viscosity, emulsification, and preservation.
      • Create a pleasant user experience.

    Examples of Functional Ingredients:

    • Solvents (Water, Glycerin, Propylene Glycol):
      • Dissolve other ingredients.
      • Form the base of many skincare products.
    • Emulsifiers (Cetearyl Alcohol, Polysorbate 20, Stearic Acid):
      • Blend oil and water-based ingredients.
      • Create stable emulsions (creams, lotions).
    • Preservatives (Phenoxyethanol, Parabens, Potassium Sorbate):
      • Prevent bacterial and fungal growth.
      • Extend the product's shelf life.
    • Viscosity Enhancers (Carbomer, Xanthan Gum, Cellulose Gum):
      • Thicken the product's texture.
      • Improve spreadability and application.
    • Stabilisers (Citric Acid):
      • Maintain the product's pH and prevent ingredient degradation.
      • Prevent unwanted chemical reactions.
    • Humectants (Glycerin, Hyaluronic acid, Propylene Glycol):
      • Draw moisture to the skin.
      • Increase skin hydration.
      • Note: some humectants are also active ingredients.
    • Emollients (Shea Butter, Jojoba Oil, Squalane):
      • Soften and smooth the skin.
      • Create a protective barrier.
    • Occlusives (Petrolatum, Mineral Oil, Beeswax):
      • Form a barrier on the skin's surface.
      • Prevent moisture loss.
    • pH Adjusters (Citric acid, Sodium hydroxide):
      • Balance the acidity or alkalinity of the product.
      • Ensure optimal product performance.
    • Chelating agents (Sodium Phytate, Tetrasodium Glutamate Diacetate):
      • Bind to metal ions, preventing them from reacting with

    Multifunctional Ingredients: Bridging the Gap

    Now, this is where it gets extra interesting - because we also have lots of ingredients that are ‘multifunctional”. That means that while they can be used as a ‘functional’ ingredient, ie. an emulsifier - they have also been proven to have a significant effect on certain skin concerns and that they can benefit the skin the way an ‘active’ ingredient can. 

    This category highlights ingredients that serve essential functional roles in a formulation while also providing clinically proven skin benefits.

    These ingredients contribute to the product's texture, stability, and overall usability while simultaneously delivering targeted results.

    Examples of Multifunctional Ingredients:

    • Olivem 1000 (Cetearyl Olivate, Sorbitan Olivate):
      • Functional: Emulsifier, creates lamellar liquid crystals that mimic the skin's lipid structure.
      • Active: Provides deep hydration, improves skin elasticity, and offers a silky, non-greasy feel.
    • Hyaluronic Acid:
      • Functional: Humectant, viscosity enhancer.
      • Active: Hydrates, plumps, and reduces the appearance of fine lines.
    • Niacinamide (Vitamin B3):
      • Functional: Stabilizer, viscosity enhancer.
      • Active: Reduces redness, strengthens the skin barrier, minimizes pores, brightens skin.
    • Glycerin:
      • Functional: Humectant, solvent.
      • Active: Hydrates, improves skin barrier function.
    • Squalane (Derived from olives or sugarcane):
      • Functional: Emollient, occlusive (light).
      • Active: Hydrates, soothes, and protects the skin; antioxidant properties.
    • Ceramides:
      • Functional: Emollient, skin-identical ingredient.
      • Active: Restores the skin barrier, reduces dryness and irritation.
    • Panthenol (Pro-Vitamin B5):
      • Functional: Humectant, emollient.
      • Active: Soothes, hydrates, and promotes skin healing.
    • Certain Plant Oils (e.g., Jojoba, Argan):
      • Functional: Emollients, occlusives (light).
      • Active: Provide essential fatty acids, antioxidants, and anti-inflammatory benefits.

    ___________________________________________________________________________

    Below is a SAMPLE Formulation and a hypothetical manufacturing method to show you the combination of Active and Functional ingredients in a formulation. 

    • You will also note that there is a ‘Water Phase’ and an‘Oil Phase’ in the formulation - that is because some ingredients are water-based/water-soluble and others are oil-based / oil-soluble.
    • When you combine water-based and oil-based ingredients in a formulation, it forms what we call an emulsion and based on the viscosity this can be a thin serum or a thicker cream and anything inbetween. 
    • This is where ‘functional’ ingredients like emulsifiers play an important role as they facilitate the blending between water and oil-based ingredients so that the formulation doesn’t separate. They can also impact the viscosity of the formulation and can work alongside viscosity enhancers to alter the texture of the formulation.
    • Whenever there is water and water-based ingredients in a formulation we need preservatives to keep the product free from pathogens and mold for example. An oil-based formulation like a face oil or cleansing balm/oil does not require a preservative system.


    SAMPLE Retinaldehyde & Peptide Brightening Serum - Emulsion Formulation:

    Phase A (Water Phase):

    • Water (Aqua): 70.0% - Functional: Solvent, base of the formulation.
    • Glycerin: 5.0% - Multifunctional: Humectant (draws moisture), solvent, viscosity enhancer.
    • Niacinamide: 3.0% - Multifunctional: Brightener, strengthens skin barrier, reduces redness.
    • Sodium Hyaluronate (Hyaluronic Acid): 0.5% - Multifunctional: Humectant, hydrates, plumps.
    • Xanthan Gum: 0.3% - Functional: Viscosity enhancer, thickener, stabiliser.


    Phase B (Oil Phase):

    • Squalane: 5.0% - Multifunctional: Emollient, light occlusive, hydrates, antioxidant.
    • Jojoba Oil: 3.0% - Multifunctional: Emollient, provides essential fatty acids.
    • Cetearyl Olivate, Sorbitan Olivate (Olivem 1000): 4.0% - Multifunctional: Emulsifier, provides hydration and a silky feel.
    • Cetyl Alcohol: 1.0% - Functional: Co-emulsifier, viscosity enhancer.


    Phase C (Active Phase):

    • Retinaldehyde: 0.05% - Active: Stimulates collagen production, reduces wrinkles, and improves texture.
    • Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7: 3.0% - Active: Signal peptides, stimulate collagen and elastin production.
    • Licorice Root Extract: 1.0% - Active: Brightens skin, and reduces hyperpigmentation.
    • Tocopherol (Vitamin E): 0.5% - Active: Antioxidant, protects against free radicals, helps stabilise retinaldehyde.

     

    Phase D (Preservative Phase):

    • Phenoxyethanol, Ethylhexylglycerin: 1.0% - Functional: Preservative (broad-spectrum).
    • Potassium Sorbate: 0.3% - Functional: preservative booster.

     

    Sample Manufacturing Process:

    1. Phase A: Combine all Phase A ingredients and heat to 70-75°C, mixing until xanthan gum is fully hydrated.
    2. Phase B: Combine all Phase B ingredients and heat to 70-75°C, mixing until uniform.
    3. Emulsification: Slowly add Phase B to Phase A, mixing vigorously using a homogenizer or high-shear mixer until a stable emulsion is formed.
    4. Cooling: Allow the emulsion to cool to below 40°C, stirring occasionally.
    5. Phase C: Add Phase C ingredients one by one, mixing thoroughly after each addition.
    6. Phase D: Add Phase D ingredients, mixing until uniform.
    7. pH Adjustment: Check and adjust the pH to 5.5-6.0 using citric acid or sodium hydroxide if necessary.
    8. Packaging: Package in an airless pump container to protect the retinaldehyde from oxidation.



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